Next imaging technologies

IOVacc is developing different kinds of innovative approaches to analysis, mining and interpretation the complex of life science imaging datas and informations.


Expertise in optical microscopy and image analysis, partial or total realization of observations and analyzes based on the specifications.
Application examples :

● Migration Study, proliferation, toxicity, apoptosis, cell adhesion (primary neuron culture, fibroblast …)

● Calcium Imaging in vitro (Fura 2, Fluorescent 3 …)

● Mitochondrial dynamics, morphology, membrane potential, mobility

● Shoot analysis of neurons in vitro (primary DRG neurons Culture, hippocampus, cortex)

● Imaging on small animals (Cell Tracking under the skin, mitochondria …)

● Nonlinear microscopy without marking the second and third harmonic generation (SHG / TGH), Coherent Anti-Stokes Raman Scattering (CARS)

● Three-dimensional imaging of the cell to the whole organism, Life Imaging

● Virtual blades (blade Scanning histologies (coloring or fluorescence)

IOVacc trying to differentiate themselves in the complex analysis of several sciences: genomics, transcriptomics, cell and molecular biology, immuno-oncology …

The innovative approach IOVacc based on biomedical knowledge of the entire human organism during development of the first stages of the drug by optical analysis of the results obtained in order to reach conclusions when interpreting the data analyzed.

Image analysis with specialized software such as (Metamoph, Definiens, Image J, Imaris, Huygens):

● Deconvolution

● 3D visualization

● Quantification 2D / 3D / 4D

● Segmentation

● Tracking

● Co-location

● Automation

Our goal is to combine and compile the latest publications in the field of genome and skin expression, in order to conduct a more efficient reading of analyzes in clinical trials.

Our technology 3D NERVSKIN is a revolution in term of science and efficiency of preclinical datas.


Multiphoton microscopy is a powerful tool in deep tissue imaging and allows due to nonlinear phenomena that can generate, obtain morpho-functional informations on a tissue, without requiring any markings. The objective of this technology is to use the new multiphoton microscope to develop a method for the in vivo phenomenon of observation without labeling.

We have developed an imaging technique, for in vivo, to visualize structural changes without markings. We turned to the multiphoton imaging to visualize collagen, myelin lipids and other structures, for generating second and third harmonic, providing morpho-functional informations without requiring markings.

Raman microscopy stimulated known CARS (Coherent Anti-Stokes Raman scattering) is a new imaging method whose contrast derives from the intrinsic selective resonant excitation of molecular vibrations of a link or set of links chemical. The CARS signal is much more effective than the spontaneous Raman scattering process since the molecular vibration is specifically forced by frequency difference. CARS is a multiphoton process which require the use of pulsed lasers whose beams are spatially and temporally synchronized and occurs only at the focal point of a microscope objective for obtaining three-dimensional images by scanning.